091 Vemurafenib impairs the repair of UV radiation induced DNA damage
نویسندگان
چکیده
منابع مشابه
Hereditary Disorders with Defective Repair of UV-Induced DNA Damage
Nucleotide excision repair (NER) is an essential system for correcting ultraviolet (UV)-induced DNA damage. Lesions remaining in DNA due to reduced capacity of NER may result in cellular death, premature aging, mutagenesis and carcinogenesis of the skin. So, NER is an important protection against these changes. There are three representative genodermatoses resulting from genetic defects in NER:...
متن کاملExcision repair of UV radiation-induced DNA damage in Caenorhabditis elegans.
Radioimmunoassays were used to monitor the removal of antibody-binding sites associated with the two major UV radiation-induced DNA photoproducts [cyclobutane dimers and (6-4) photoproducts]. Unlike with cultured human cells, where (6-4) photoproducts are removed more rapidly than cyclobutane dimers, the kinetics of repair were similar for both lesions. Repair capacity in wild type diminished t...
متن کاملImmunological reaction of UV-induced radiation damage in coliphage DNA.
Denatured DNA of coliphage T1, poly-dT and dTpT were UV-irradiated (2537 A) and conjugated to methylated bovine serum albumin. These molecules act as haptens after injection into rabbits. Antibodies are predominantly formed against UV-induced cyclobutane-type of cis-synthymine dimers. They belong to the IgG-type of antibody molecules. Antigen-antibody complexes were detected by means of the CsC...
متن کاملUV-induced DNA damage and repair: a review.
Increases in ultraviolet radiation at the Earth's surface due to the depletion of the stratospheric ozone layer have recently fuelled interest in the mechanisms of various effects it might have on organisms. DNA is certainly one of the key targets for UV-induced damage in a variety of organisms ranging from bacteria to humans. UV radiation induces two of the most abundant mutagenic and cytotoxi...
متن کاملChromatin Structure Following UV-Induced DNA Damage—Repair or Death?
In eukaryotes, DNA is compacted into a complex structure known as chromatin. The unravelling of DNA is a crucial step in DNA repair, replication, transcription and recombination as this allows access to DNA for these processes. Failure to package DNA into the nucleosome, the individual unit of chromatin, can lead to genomic instability, driving a cell into apoptosis, senescence, or cellular pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.02.105